Friday, September 18, 2015

miR-29c regulates NAV3 protein expression in a transgenic mouse model of Alzheimer׳s disease

Yuanyuan Zong, Pin Yu, Hongxia Cheng, Hailin Wang, Xiaoying Wang, Chunlian Liang, Hua Zhu, Yejun Qin, Chuan Qin




Abstract
The microRNA-29 family (miRNA-29s) has three mature members, miR-29a, miR-29b and miR-29c, which have been implicated in the regulation of the pathogenesis of Alzheimer׳s disease (AD). The miR-29 family members exhibit differential regulation in various diseases and different subcellular distribution. In the present study, we initially investigated differential expression of miR-29c in the hippocampus and the frontal cortex of the young APPswe/PSΔE9 mouse brain, accompanied by inverse expression of neurone navigator 3 (NAV3), a regulator of axon guidance. We observed that miR-29c directly mediated downregulation of NAV3 protein expression in vitro. The mouse NAV3 mRNA has a functional miR-29c binding site in the 3′ UTR, which localized in the position between 830–836 bp of 3′UTR region, slightly different from human NAV3 mRNA binding site. These observations suggest that miR-29c may be involved in neurodegenerative processes by regulating NAV3 expression in the young AD mouse.

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Keywords:
miR-29c, Alzheimer׳s disease, NAV3 protein, microRNAs, APPswe/PSΔE9 mice 
 
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