Iain A Drummond
Abstract
Nearly all cells have cilia, microtubule based projections from the apical cell surface, and nearly all cells use them in essential and unique ways. How
mammalian cilia function in vivo as mechanosensors, signal transducers, or in fluid propulsion has been difficult to study due to lack of tools for live imaging
of cilia. A new transgenic mouse that enables tissuespecific GFP labeling of cilia creates new opportunities for using live imaging to understand cilium function
and to better characterize the many genetic models of ciliopathies.
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